Lab-on-a chip: nanobiosensors for point-of-care diagnostics
DOI:
https://doi.org/10.62741/ahrj.v2i4.55Keywords:
Diagnosis, nanobiosensors, pathogen, Point-of-careAbstract
Introduction: Growing demand for fast, sensitive and simple diagnostic tools are driving the innovation of nanobiosensors, for point-of-care application. By combining state-of-the-art biosensing technologies and micro-scale platforms, they facilitate rapid in situ analyses of disease biomarkers for infectious diseases, cancer, and a wide range of diseases. There are several new modified nanomaterial-based biosensors (including modified graphene, carbon nanotubes, quantum dots and noble metals nanoparticles) that could offer desired sensitivity and specificity, combined with microfluidic and wireless systems.
Objectives: The present paper aims to review the technical aspects of the new generation of biosensors and its potential uses in point-of-care evidence-based diagnostics.
Methodology: A literature search was conducted across PubMed, ScienceDirect, and MDPI, focusing on peer-reviewed articles from 2010 to 2024, with priority given to studies from 2019–2024. A total of 63 articles were identified; 47 were included in this review, and 16 were excluded based on relevance.
Results: We provide examples of the clinical relevance of these tools from pathogen detection as well as oncology. The use of nanobiosensing for decentralized/point-of-care/personalized health care has great potential even in the context of remaining challenges including standardization practices and biofouling related problems, especially when multidisciplinary innovations are united.
Conclusion: In conclusion, while challenges continue to remain such as standardization and biofouling, the future of nanobiosensors as a key component in decentralized and personalized healthcare remains bright when supported by innovations stemming from interdisciplinary collaboration.
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